8 Drugs that Don’t Mix with Prozac

Drugs & Alcohol

Prozac is a common antidepressant prescribed to treat depression that cannot be mixed with other medications or illicit drugs. Doctors are diagnosing more and more Americans with depression. With rising depression rates, it’s no surprise that 13% of Americans take antidepressants. The depressants help stabilize and lift their moods, so they can live their life to the fullest.

Prozac, otherwise known as fluoxetine, is a type of antidepressant known as selective serotonin reuptake inhibitor (SSRI). It’s used to treat not only depression, but also bulimia, obsessive-compulsive disorder (OCD), and panic disorders. This medication is quite versatile, and can treat a wide array of disorders and conditions.

Most doctors prescribe a dose of 10mg to 80mg of Prozac to patients. Before this medication is prescribed, the doctors will want a detailed medical history. This is because Prozac can and will react negatively to many other medications and drugs. The adverse reactions can even turn deadly.

It’s important that a patient is detoxed from all other medications and drugs before they start Prozac. Here are 8 drugs that don’t mix with Prozac. When mixed, it may cause unwanted reactions and side effects. Those who are taking Prozac should be aware of these drug interactions to avoid having to deal with unwanted side effects.

Prozac and Alcohol

#1 Prozac and Alcohol

Drinking is a big no-no when taking Prozac. Alcohol is a depressant that will slow down and even inhibit certain messages and signals in your brain. Like alcohol, Prozac can have similar effects. For one, it can cause tiredness and can interfere with one’s balance and motor function.

Those who choose to combine Prozac and alcohol together will experience an increased sedative effect. This effect can be quite dangerous. For example, it increases the risk of falls and injuries, and it promotes poor decision-making abilities. Essentially, these two drugs amplify and magnify each other’s effects when mixed together.

Prozac is often not prescribed to patients with an alcohol addiction or who frequently consume alcohol. Most doctors will want to discuss the dangers of mixing the two at length, so patients know not to do it. Combining both Prozac and alcohol can also lead to many unwanted side effects, like:

  • Dizziness
  • Extreme fatigue and weakness
  • Feeling of hopelessness
  • Suicidal thoughts

Alcohol can prevent Prozac from working properly in the body. This means that patients won’t be getting the full effect. Prozac won’t stop the sedative effects of alcohol, and alcohol won’t allow Prozac to have an optimal effect in treating depression.

When Can You Drink Alcohol Again?

Unlike with many other medications, a patient cannot simply wait a few hours after taking Prozac to drink. This is because Prozac has a fairly long half-life in the body, and will remain as a metabolite for quite some time.

The half-life of fluoxetine ranges from 2 to 7 days. This means that it can take anywhere from 11 to 38.5 days for the body to clear Prozac completely. This means that patients can’t and shouldn’t drink alcohol for at least up to a month and a half after they’ve last taken Prozac.

Even if the active ingredient of fluoxetine is successfully removed from the body, it doesn’t mean that its metabolites are cleared as well. Just like fluoxetine, the metabolites can react with alcohol as well. The primary metabolite of fluoxetine is known as norfluoxetine. This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get rid of this compound.

If a patient is trying to control or manage his or her drinking, there’s some good news to all of this. Some researches have shown that Prozac may be capable of curbing physical cravings. After detoxing from alcohol, Prozac may help treat an alcohol addiction.

Prozac and Cocaine

#2 Prozac and Cocaine

Just like with alcohol, research has shown that Prozac reacts with illicit drugs as well. Since Prozac is a serotonin reuptake inhibitor, it can enhance the stimulating effects of cocaine use. Drug users may feel a more potent high, or may feel more energetic when combining both drugs together.

Unfortunately, the mechanism of action between how Prozac interferes with cocaine is still not known. The best theory is that Prozac interferes with enzymes that metabolize cocaine. Those who take Prozac with cocaine will have higher concentrations of cocaine in the body at the end of the day. This is because the body is unable to process and metabolize the drug efficiently.

Both drugs should not be mixed together, as it opens up the potential for an increased risk of overdoses. The two drugs may overwhelm the body. Also, since the body is unable to metabolize the cocaine, large doses used cocaine addicts may easily cause overdoses and other unwanted side effects.

Current Research Involving Concurrent Prozac and Cocaine Use

Surprisingly, when administered by a professional, Prozac may have the potential and ability to treat cocaine abuse. Studies have shown that Prozac can attenuate the mydriatic effects of cocaine. It can decrease positive mood effects without causing any major physiologic interactions in the body.

It’s important to note that patients should not try to self-medicate themselves. There’s a fine line between treatment and a dangerous dose. Those who attempt to self-medicate may put themselves in a dangerous situation. After all, patients are under careful supervision if prescribed by a doctor.

Prozac and Marijuana

#3 Prozac and Marijuana

One of the top 15 most used drugs in America is marijuana. Patients who are taking Prozac to treat depression are also likely to self-medicate with marijuana. After all, both drugs are designed to help lift a person’s mood, and leave them in better spirits.

Unfortunately, combining the two may not necessarily be safe. There is only a moderate risk involved with mixing marijuana and Prozac. The side effects to look out for include increased sedative effects and hypomania.

Hypomania is a mild form of mania. It is often characterized by periods of hyperactivity and elation. This can have a lasting effect on one’s psychological health. We’ll explore this symptom below.

Another key feature to point out is that research shows that those who take Prozac and marijuana together are less likely to stay complacent with their treatment plan. They are more likely to miss a dose or stop taking their medications completely.

Symptoms of Hypomania

Since hypomania is the main side effect of Prozac and cannabis use, it’s a good idea to familiarize with the symptoms of this condition. Hypomania is classified as the presence of 3 of the following symptoms:

  • An inflated self-esteem, self-confident or grandiosity
  • A decreased need for sleep
  • An excessive involvement in risky, but pleasurable activities
  • Increased distractibility and an inability to stay focused
  • Overly talkative behavior
  • Need to participate in goal-directed activities
  • Racing thoughts or subjective experiences

Fortunately, hypomanic episodes do not necessitate hospitalization. This is mainly because it does not involve any psychotic effects and features, like hallucinations. With that said, hypomania can completely change a person’s behavior. For example, he or she may become a lot more sociable or outgoing.

Prozac and Prescription Opioid Painkillers

#4 Prozac and Prescription Opioid Painkillers

Opioid use in America has gotten out of hand; overdose rates are skyrocketing to unfathomable heights. With that said, Prozac and opioids don’t mix well together. However, the effects of mixing the two drugs will vary depending on the type of opioid that is used. Some opioids won’t elicit a reaction even when combined with Prozac. To avoid any adverse reactions, it’s best to avoid mixing the two different types altogether. It’s not worth the risk.

Since the side effects will vary depending on the type of drug, let’s take a look at some examples. Some of the most commonly taken opioids include methadone, fentanyl and naloxone.


Methadone is often used in Opiate Replacement Therapy (ORT). It plays a crucial role in opioid detox. Concurrent use of Prozac and methadone can result in an increased risk of arrhythmia. While this side effect is a bit rare, it can be life threatening. Side effects are more prevalent among patients struggling with a heart condition.

Depending on each patient’s situation, some doctors may prescribe Prozac and methadone together. These patients will need around-the-clock supervision, as their condition is much more critical. Some other common side effects of taking Prozac and methadone together include:

  • Fainting
  • Heart palpitations
  • Lightheadedness
  • Shortness of breath
  • Sudden dizziness

Those who experience consistent and persistent side effects should speak to their doctor. The same can be said for those who feel that the side effects are worsening. In these situations, the doctor may recommend switching to another drug combination, or may decide to stop prescribing one of the drugs completely.


Those who mix fentanyl with Prozac are more likely to develop serotonin syndrome. This happens when large levels of serotonin can accumulate within the body. They overwhelm the entire system. The side effects of this condition include:

  • Blurred vision
  • Changes in blood pressure
  • Confusion
  • Fever
  • Hallucinations
  • Increased heart rate
  • Loss of balance and coordination
  • Muscle spasm and/or stiffness
  • Nausea
  • Profuse sweating
  • Shaking or shivering
  • Seizures and tremors
  • Vomiting and diarrhea

In worst-case scenarios, serotonin syndrome can result in coma or death. It’s vital that a doctor is aware of when the two drugs are being mixed together. It’s also important to note that a serotonin syndrome can be treated by discontinuing all medications. Patients who are extremely agitated may take benzodiazepines to help ease any side effects they experience.

Other Opioids Containing Codeine, Hydrocodone or Naloxone

Some prescription drugs aren’t necessarily classified as opioids; however, they do contain opioids in them. Common ingredients include codeine, hydrocodone or naloxone. These drugs may also have a negative reaction in the body when mixed with Prozac. They may result in the development of serotonin syndrome, as well as many other side effects.

Prozac and Over-the-Counter Painkillers

#5 Prozac and Over-the-Counter Painkillers

In addition to the adverse effects that can be expected with prescription opioids, over-the-counter painkillers may also react negatively with Prozac. Both drugs may target the same protein receptors in the brain. Over-the-counter painkillers can block the effectiveness of antidepressants, like Prozac. However, the exact mechanism of action is unknown. Most scientists theorize that painkiller pills may disrupt selective serotonin reuptake inhibitors (SSRIs).

The reaction between the two drugs is not just a theory. It’s been tested time and time again. Scientists have noticed that patients who take acetaminophen or other over-the-counter painkillers are less likely to experience relief from Prozac. They will still struggle with depression. In fact, their progress may be equivalent to a person who is not being medicated with Prozac.

While the results are known, no one knows exactly just how large of a dose of painkiller will interfere with Prozac. Some patients may find that even a small dose of painkillers can render Prozac useless. If a patient is not responding to Prozac, the doctor will want to figure out there was a concurrent use of pain pills.

Prozac and Benzodiazepines

#6 Prozac and Benzodiazepines

Benzodiazepines are also common medication used in America. Both are often used to treat anxiety. While they may both be effective, combining the two may not always yield positive results. Different benzodiazepines can cause various unwanted side effects.

For example, Xanax is often used to treat anxiety. When paired with Prozac, the two drugs will play off of one another and cause excessive drowsiness. This may prevent some patients from being able to run daily errands. Both drugs may also increase the concentration of each drug in the bloodstream. It may also cause the drugs to stay for a longer amount of time in the body.

While patients shouldn’t decide to mix the two drugs together at a whim, some doctors may choose to combine the two when treating anxiety. It’s important to note that the mixing of both drugs is only safe when done under medical supervision.

Some studies have shown that combination therapy may be more effective than just taking one drug at a time. It’s particularly effective among patients with comorbid anxiety and depression.

Prozac and Stimulants

#7 Prozac and Stimulants Used to Treat ADHD

Among all the drugs that don’t mix well with Prozac, stimulants prescribed for ADHD is one of the biggest ones to remember. Amphetamines, like Adderall, interfere with the chemical pathway of Prozac and vice versa. Most importantly, however, is that Prozac will significantly block the metabolic pathway of amphetamines. This means that it becomes a lot easier for patients to overdose on amphetamines.

Many patients take Adderall to deal with their inability to focus, and may accidentally mix the two drugs together if they also struggle with anxiety or depression. When Prozac is mixed with Adderall, patients can also expect certain side effects like:

  • Anxiety
  • Jitteriness
  • Nervousness
  • Restlessness
  • Racing thoughts

Combining these two drugs can also increase one’s risk of developing serotonin syndrome. This syndrome comes with some nasty side effects, and can even result in coma or death. This syndrome is a common side effect of mixing Prozac with any other type of drug.

Mixing the two drugs can also cause patients to become angry and irrational. They may be unable to sleep and eat, and may also become destructive. Their entire personality and behavior may change drastically. In most cases, close family members and friends should notice the behavioral changes almost immediately.

#8 Prozac and Methamphetamines

Methamphetamine use has been climbing at alarming rates. In 2013, more than 500,000 million people admitted to using and abusing this drug. Unfortunately, the numbers have only continued to rise over the years.

Much like with many other drugs, it’s not wise to mix Prozac and methamphetamines together. The two react negatively off of one another and can cause an array of unwanted side effects. In particular, it can also result in the development of serotonin syndrome, which can be quite deadly.

It’s definitely not worth mixing the two. Those who do may have a difficult time recovering, and may also sustain permanent bodily damages to the brain and to the nerves. The extent of the damage will depend on the dose taken, one’s biological makeup, among many other factors.

Use Prozac As Prescribed

Simply put, Prozac is not a drug that should be mixed with any other medications or substances. It reacts poorly with almost every other chemical compound. In fact, Drugs.com lists 1833 brand and generic drug names that are known to have major interactions with Prozac.

If you are prescribed Prozac by a doctor, make sure that you take the medication as prescribed. Don’t mix multiple substances together. If you do, it may result in some dire consequences. You should also speak with your doctor to fully understand the consequences of mixing certain substances together with Prozac.

With that said, if you’re addicted to other drugs or Prozac, it’s time to take action now. Contact us for more information on the various types of polydrug use addiction programs we offer. We’d be more than happy to walk you through each step, so you know what to expect on your road to recovery.

Frequently Asked Questions

What is Prozac?

Prozac is a medication that has been classified as an antidepressant. It is a selective serotonin reuptake inhibitor, and it is often sold under its brand name, fluoxetine.

Prozac was first approved for use by the FDA in 1988. Since that time, it has become one of the most widely prescribed medications in the United States. Although it is one of the older antidepressants on the market, it is still widely prescribed today.

This medication is available as a tablet, capsule and as a liquid. It has a delayed-release formulation that a lot of doctors prefer. That means that it releases a little bit of the medication in the body throughout the day. Most doctors prefer to use it for adults, but it can be prescribed to children who are over ten years of age.

What is Prozac Used to Treat?

Most doctors use Prozac to treat several different types of mental health issues. It is commonly prescribed to treat panic disorder, anxiety, obsessive-compulsive disorder and major depressive disorder.

When this medication is taken as prescribed, it works very well. But every effort should be made to adhere to doctor’s orders when on Prozac. That means never mixing it with other drugs without a physician’s permission.

Can Prozac be Taken Long-Term?

According to the National Alliance on Mental Illness, there are no known problems associated with taking Prozac long-term. When it is used as directed, it is very safe and effective.

How Does Marijuana Impact the Potency of Prozac?

Researchers do not completely understand how the use of marijuana can affect antidepressant medications. They have questions about the pharmacokinetics, which means that they are unsure how the body will absorb, process and dispose of Prozac with the addiction of weed.

It is possible that using cannabis can inhibit the way the body metabolizes Prozac. If that is the case, it means that the drug would be much more potent in the body. As a result, a doctor could be prescribing a higher dose than is actually needed, which can make a person’s symptoms much worse. It can also delay the effects of the medication so that the patient does not get relief as quickly as they would otherwise.

If you currently use marijuana and you take or will be taking Prozac (or any other antidepressant) it is important to talk with your doctor. They need to be aware of everything you take, and that includes letting them know if you smoke weed. The more your doctor knows, the better care they can offer you for your symptoms.

Are There Better Alternatives to Prozac?

There is no denying that Prozac has been around for a very long time. It makes sense to assume that it might not be the best option for everyone who suffers from depression, anxiety or a related mental health condition. But it can help to know that you have alternatives available to you if you need them.

There are many medications that might work well to treat your symptoms, and not all of them are SSRIs. For example, your doctor might want to have you try any of the following:

  • Wellbutrin
  • Cymbalta
  • Effexor
  • Pristiq
  • Celexa
  • Lexapro
  • Luvox
  • Paxil
  • Zoloft

One of the above might be a better option for you. There are also other steps that can be taken as well, such as:

  • Increasing or decreasing your dose of Prozac.
  • Adding an antipsychotic medication to the Prozac, such as Abilify or Seroquel XR.
  • Adding talk therapy to your treatment regimen.
  • Having you start participating in peer support group.
  • Lifestyle changes such as better nutrition and more exercise.

A lot of people start using alcohol or drugs in addition to Prozac to help boost the drug’s effects. But that can be very dangerous. It is best to leave this in the hands of experts who know what type of treatment will work for you.

What is Serotonin Syndrome?

Serotonin syndrome is a condition that causes the body to have too much serotonin, which is a chemical that is produced by the body’s nerve cells. This is a potentially life-threatening drug reaction that needs immediate treatment.

Serotonin syndrome, or SS, can develop when two different medications that impact serotonin levels in the body are taken at the same time. When they are used together, they can cause too much serotonin to be released or stay in the brain.

There are many drugs that have been associated with SS, and they include both prescription medications and illegal substances. They include:

  • Triptans, which are often taken for migraines
  • Celexa
  • Prozac
  • Zoloft
  • Paxil
  • Lexapro
  • Cymbalta
  • Effexor
  • Monoamine oxidase inhibitors (MAOIs)
  • Demerol
  • Dextromethorphan
  • Cocaine
  • Amphetamines
  • LSD
  • Ecstasy

The symptoms of SS can include:

  • Hallucinations
  • Rapid blood pressure fluctuations
  • Diarrhea
  • Feeling agitated or restless
  • A fast heart rate
  • An increased body temperature
  • Nausea and vomiting
  • Loss of coordination
  • Overactive reflexes
  • Fevers
  • Tremors
  • Shivering

If you are diagnosed with SS, you will likely be admitted to the hospital for at least 24 hours. You may be given medications to help with your symptoms and to guard against seizures. If your condition is deemed to be life-threatening, you may be given medications to paralyze your muscles while you are put on a temporary breathing machine. This can help prevent further muscle damage from taking place.

What Other Medications Can Impact How Prozac Works in the Body?

You should never take Prozac if it has been less than six weeks since you took an MAOI medication. The same is true if you have taken another type of antidepressant, a prescription painkiller or a migraine medication like Imitrex.

Taking Prozac can also affect the following medications and how they work:

  • Anticonvulsants
  • Some antipsychotics
  • Benzodiazepines
  • Straterra
  • Coumadin
  • Tricyclic antidepressants
  • Beta blockers
  • Codeine
  • Aspirin
  • Ibuprofen

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8 Drugs and Prozac

2020-09-01T17:00:45+00:00August 8th, 2020|22 Comments


  1. Peter January 1, 2019 at 7:39 am

    Wasn’t aware of these side effects of mixing with dexamphetamine. Same Doctor gave me both whilst other doctors gave me massive doses of Lyrica 1200mg pd, OxyContin 160mg pd and clonazapam 4mg per day. Interesting read.

    • Northpoint Staff January 4, 2019 at 2:27 am

      We are glad the article had some tidbits for you!

    • Happy April 23, 2019 at 6:15 pm

      Happened to me too…dire consequences…however now off Prozac and feeling better than I have I. Years mentally …off opiates off benzodiazepines..anxiety GONE!!!!! Pain still sucks butt …still but better pain wise than when treating with morphine holy crap…can’t believe it…not angry not irrational

  2. Melinda January 11, 2019 at 7:10 pm

    Can Prozac be taken with MyDayis for depression and anxiety?

    • NorthPoint Staff January 21, 2019 at 4:53 pm

      Unfortunately, we cannot discuss medications because it is dependent upon your medical history. If you are concerned, please reach out to your doctor to further discuss your options.

    • David Tatum March 31, 2019 at 3:18 pm

      Yes I take Prozac and bousporne but you really should all your Dr about that.

  3. JohnyStevensBKAJB February 10, 2019 at 9:32 pm


    • NorthPoint Staff February 15, 2019 at 5:26 pm

      Thank you for sharing your personal experiences, JB! We wish you nothing but continued success!

  4. Dawn February 12, 2019 at 8:20 pm

    My partner of 2 yrs mixes pozac, weed or vape and booze (2-3 beers and or wine on avg) on a regular basis. He’s 44. Has often had violent outbursts out of nowhere, sexual impotency and porn addiction due to sexual impotency. somtimes throws up when binges weed all day. Functions at work..seems hypomanic and euphoric often. legs twitch horribly when at rest. H kept a lot from me for a ling time (except the explosive outbursts once in a while) I’m really concerned.

  5. Mom April 1, 2019 at 12:50 pm

    #7 warns against Prozac with Adderall. Does the same happen between Prozac and Concerta as it is also a stimulant?

    • NorthPoint Staff April 2, 2019 at 4:26 pm

      It could likely have a similar interaction, however, it would determine upon the makeup of the medication itself. If you are concerned about any interactions please reach out to your medical doctor.

    • Tttt June 11, 2019 at 7:12 am

      My wife takes prozac and uses meth, I can say that it is a terrible idea. She freaks out for no reason screams hits herself says that I’m cheating everytime I leave or she sleeps. She says people are in the house all the time, every time I leave she thinks the house is getting raided. I know meth causes paranoia but weve been using together for two years and it was never like this. (Shes only been on prozac for about two to three weeks.)

  6. Mable Curtis April 1, 2019 at 2:23 pm

    My daughter in 20 mg of Prozac for a month now. Since starting she very mean, want to fight curse say things that are not normal. Cry hurts want help very violent and angry none of these occurred before being put on Prozac. Can Benadryl for her allergies, ibruophen, goody powder or alleve interfere wit Prozac and be the cause. She has arthritis and headaches and take the over counter meds. Yesterday she had an very bad day to the point we wait8ng on dr to call us back to see if she can get to mental hospital. For now she is sleeping resting well. Just trying to determine if Prozac cause her to be worse or if over ctr meds causing these horrible symptoms .

    • NorthPoint Staff April 2, 2019 at 4:24 pm

      It is definitely possible that the over the counter medications are interacting with her Prozac. It would be best to reach out to her medical doctor and/or pharmacist that has her full medical history to help determine the interactions you are concerned about. We wish you both all the best.

  7. Linette May 4, 2019 at 1:43 am

    I’m at my wit’s end. I’ve suffered from depression and anxiety my whole life. I’m 46. On and off several meds because of stupid interactions. If I treat my depression, I can’t take the allergy medications I need or the only antibiotic I’m not allergic to, zpack. So do I just give up and suffer with depression or suffer from severe allergies, unable to take a zpack for a bad tooth or flu? It’s one or the other? Really? I don’t drink alcohol, do any drugs of any sort. I have a psychiatrist who just says, there’s nothing we can do. Does everyone on Prozac go without antibiotics when needed? I almost died from being on 20 mg. Prozac and given a zpack! Is there any anti depression medication that you can take with a zpack, and allergy meds or ibuprofen for that matter? Please help!

  8. Lin July 13, 2019 at 1:12 am

    I had a Prozac/Benedryl reaction a few years before the internet was everywhere. I had been a Prozac user for years and was prescribed Benedryl for an allergic reaction to penicillin. Severe confusion made it a challenge but I was finally able to call a friend (thanks to speed dial) and asked, “Am I speaking English?” Very unsettling.

  9. G August 5, 2019 at 7:09 pm

    I don’t suffer from depression, just the occasional panic anxiety attack.
    I am thinking of taking Prozac, but does it really go bad with alcohol? I am a social drinker who loves dinners and wine.
    Is it that bad?

    • NorthPoint Staff August 7, 2019 at 3:09 pm

      Adding alcohol and Prozac can be dangerous as they are both depressants and can increase the level of sedation. You may want to discuss this with your doctor and/or not take the Prozac when you plan to drink and vice versa.

  10. Janet lee Mclaughlin August 18, 2019 at 11:39 pm

    Lost my hair and teeth due to taking Prozac!!! No other medications taken during this time,no alcoholic beverages,or pain medications. I’m filing lawsuit against Prozac!

    • NorthPoint Staff August 19, 2019 at 3:49 pm

      Thank you for sharing your experiences. We wish you all the best!

  11. Louis September 16, 2019 at 4:34 am

    What about mixing caffeine with Prozac; what about nicotine?
    Additionally it would also be interesting to learn how Zyrtec interacts with Prozac; how Aleve interacts with it, as well as the sleep aid, Dipenhydromine.

    I just gave up alcohol because it was very obviously messing with my Prozac. But I replaced the alcohol with nicotine (smoking).

    • NorthPoint Staff September 16, 2019 at 4:48 pm

      Thanks for the suggestions, check back for future updates!

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